Association of Elevated xidized Low Density Lipoprotein-� -Glycoprotein with Lipoprotein(a) and Malondialdehyde Reflect the Risk for Coronary Artery Diseases

Yingyot Kaewnate, Somchai Mongkolporn, Jira Pattanapohongsag, Orathai Tangvarasittichai, Surapon Tangvarasittichai

Abstract


Elevation of oxidized low density lipoprotein-ß2-Glycoprotein ( OxLDL-ß2-GPI ) and lipoprotein(a) Lp(a) plays a central role in the development of atherosclerosis. The elevation of OxLDL-ß2-GPIand Lp(a) levels in patients with stable coronary artery disease (CAD) patients demonstrated as the effective risk factors for future CAD. The study included 6 diabetes mellitus patients with stable CAD complication (CAD_DM) and 6 age matched healthy controls. OxLDL-ß2-GPI, Lp(a), MDA levels and other metabolic variables were measured in these participants. Comparison between groups was assessed by using Mann-Whitney U test. Bivariate correlation of variables was assessed by Spearmann rank correlation. All data analysis was performed by using SPSS version 13.0. OxLDL-ß2-GPI, Lp(a), MDA and other metabolic variables were signiicantly higher in CAD_DM patients than healthy controls (p < 0.05). n bivariate correlation, OxLDL-ß2-GPIhad signiicant correlation with Lp(a), MDA and other CAD risk factors in CAD_DM patients (p < 0.05). We also used the mutivariate forward stepwise linear regression analysis of the signiicant variables showed that Lp(a) (ß = 0.574, R square=0.330, p < 0.001 ), HDL-C (ß=0.357 , R square=0.457 , p= 0.009) and MDA (ß=0.352 , R square=0.565, p=0.008) were independent predictors of OxLDL-ß2-GPIin CAD_DM patients. We also set the cut-off levels of these markers by using ROC curve. Elevated OxLDL-ß2-GPI, Lp(a), and MDA levels in patients with CAD despite being clinically stable and under medical treatment. These may be useful as effective risk markers for future CAD.

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