RAPD-fingerprint patterns of metallo--lactamase gene in Acinetobacter baumannii isolated from patients

Waraporn Daeng-art, Thanee Wongchai, Sirilak Teeraputon

Abstract


Acinetobacter baumannii is an opportunistic infection and a significant  nosocomial     infection which is often multi-drug resistance with numbers of outbreak rising steadily. The study of the spread of drug resistant infections in hospital helps to explain the situation of drug resistance of bacteria, the selection of appropriate antimicrobial agents and information on preventing the spread of drug-resistant infections in hospitals. This study used random amplified polymorphic DNA (RAPD) technique to investigate DNA fingerprint in 31 clinical isolates of A. baumannii carrying metallo-β-lactamase genes from 2 hospitals. Seventeen different RAPD-fingerprint patterns were found with strains having similar or closely related patterns which suggested the spreading within the hospitals of the drug resistant A. baumannii. Therefore, an effective hospital infection control program and continuous surveillance are necessary to monitor the spread of these strains in order to help preventing the spread of infection in hospitals.


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