Antioxidant status and glucose-6-phospahte dehydrogenase (G6PD) activity after acute exhausted exercise in G6PD Viangchan variants

Makamas Chanda, Duangdao Nantakomol, Daroonwan Suksom, Attakorn Palasuwan


Erythrocytes of glucose-6-phosphate dehydrogenase (G6PD) mutant individuals are susceptible to oxidative damage leading to easier deterioration than erythrocytes of normal G6PD counterparts. This study aimed to investigate the level of oxidative damage, lipid peroxidation and total antioxidant status, and G6PD activity in blood after acute exhausted exercise. Eighteen female subjects in each group of G6PD Viangchan variant and G6PD normal were tested following modified Bruce Protocol by running on a treadmill until the maximal oxygen uptake was reached. Blood samples for antioxidant analysis were taken before and immediately after the exercise and at 45 min after a bout of exercise. G6PD Viangchan variants showed significantly lower level of G6PD activity than G6PD normals at baseline and after exercise (p<0.05) and the enzyme activity continued to decrease in G6PD Viangchan after the exercise. Moreover, lipid peroxidation marker (malondialdehyde) increased significantly in G6PD Viangchan subjects after acute strenuous exercise comparing to G6PD normal subjects (p<0.05). Lower level of total antioxidant status was found immediately after the exercise in both groups with no significant differences. Our findings suggested that persons with G6PD Viangchan mutation are more susceptible to oxidative damage and have a higher risk of oxidation in blood after an acute strenuous exercise compared to normal G6PD individuals.

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