Bacterial Drug Resistance in Buddhachinaraj Hospital between 2007 to 2009

Mujarin Tiloklurs, Parichat Thanyathada


The surveillance on bacterial drug resistance was carried out at Buddhachinaraj

hospital between 2007 to 2009. The study of the bacterial prevalence showed

that Escherichiae coli was the most common organism found follower by Acinetobacter

baumannii (Multiple drug resistance, MDR) and Pseudomonas aeruginosa. The importance

problematic bacteria were Methicillin Resistant S.aureus (MRSA), E.coli (ESBLs), Klebsiella

pneumoniae (ESBLs), Ac.baumanii (MDR), and Streptococus pneumoniae (Drug Resistant

S.pneumoniae, DRSP). Because the percentage of their drug resistance were increased

from 26 to 31%, 28 to 34%, 45 to 49%, 69 to 73%, and 60 to 67%, respectively while

the resistance of Ps.aeruginosa (MDR) was not increased. The results of susceptibility

test showed the declining in sensitivity of E.coil (ESBLs), K.pneumoniae (ESBLs), and

Ac.baumanii (MDR) to Cefoperazone / Sulbactam from 86 to 50%, 51 to 17 and 75

to 21%. The susceptible of Ps.aeruginosa (MDR) to this antibiotic was decreased

to 24% in 2009. But both of these organisms , E.coli (ESBLs), and K.pneumoniae

(ESBLs), showed high sensitive to Carbapenem, 99-100%. The sensitivity of Ps. aeruginosa

(MDR) to Imipenem was declined from 54 to 27% whereas that of Ac. baumanii (MDR)

was decreased to 11% in 2009. Both of these organism still sensitive to Colistin. MRSA

was well sensitive to fosfomycin and rifampicin. There was no report of MRSA resistant

to Vancomycin. The sensitivity of S. pneumoniae to Penicillin was decreased from 40 to

33%. The results of this surveillance might be useful for establishment the guideline for

antibiotic prescription to prevent and control of bacterial drug resistance.

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