Continuous Cigarette Smoking Cause Impairment on in vitro Phagocytosis of Candida albicans

Pramoon Arooncharus, Naksit Maneerat, Siriporn Homekampung, Mujarin Sangchamni, Suranan Tirawatnapong

Abstract


Phagocytes are the second line of defense of the innate immunity. They have the major role to eliminate foreign antigens by engulfing into cells. To evaluate the phagocytic efficiency of neutrophils from the continuous cigarette smokers, blood samples were collected from the 60 healthy volunteers age 19-25 years (30 volunteers for continuous smokers and 30 others for non-smokers). The total WBCs, %neutrophils and absolute neutrophils were assayed and subsequently the NBT test and phagocytosis test were performed, respectively. The amount of total WBCs, % neutrophils and absolute neutrophils were not significantly different among the 2 groups (p > 0.05). The result of stimulated NBT test from the regular cigarette smokers was significantly lower than that of the non-smoker group (p < 0.001) according to the result of phagocytosis (p < 0.001). The results demonstrated that continuous exposure to the toxic agents from cigarette smoke cause the greatest impairment of phagocytic function of neutrophils

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