Correlation of Fasting Plasma Glucose, Hemoglobin Ale and Estimated Average Glucose Levels in Diabetic Patients with Abnormal Hemoglobin in Sirindhorn Hospital
Fasting plasma glucose (FPG) and hemoglobin Ale (HbAlc) are laboratory tests for diabetic diagnosis and monitoring of diabetic control. HbAlc value is also used for estimating average glucose levels (eAG) in diabetic patients. However, HbAlc assay may be unreliable due to interference by abnormal hemoglobin or thalassemia. The objectives of this research were to study the correlation of FPG, HbAlc and eAG in diabetic patient with abnormal hemoglobin, and to study the effect of abnormal hemoglobin on detection of HbAlc. In this study, FPG and HbA lc, which were assayed using both ion exchange HPLC and turbidimetric inhibition immunoassay, showed significantly high correlation in diabetic patients with abnormal hemoglobin. However, eAG levels calculated from HbAlc values were significantly higher than FPG levels. Moreover, HbAlc assay by ion exchange HPLC was interfered by HbE. Therefore, this interference should be concerned for HbAlc assay in diabetic patients with HbE.
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